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KMID : 0043319940170030182
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.182 ~ p.189
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A Study on the Absorption Mechanism of Drugs through Biomembranes
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Lee Chi-Ho
Kim Heun-Jo
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Abstract
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The effect of lipophilicity on the mechanisms of drug absorption through biomembranes was investigated empolying HPLC system and the fluorescence technique. Human erythrocyte ghost membranes were used as a model biomembrane. A series of four parabens (methyl, ethyl, rpopyl, and butyl) and p-hydroxybenzoic acid were used as the model drugs for lipophilicities and their partition coefficients were measured in Sorensen’s phosphate buffer solution (pH 5)/octanol system. Absorption amount of parabens through erythrocyte ghost membranes increased with an increase of lipophilicity resulted from the addition of methylene group to the n-alkyl chain of parabens. And the effect of parabens on the fluidity of ghost membrane also increased with an increase of their lipophilicities.
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KEYWORD
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Human erythrocyte ghosts, Parabens, Lipophilicity, Membrane fluidity, Drug absorption
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